Mouse Transient Global Ischemia Two-Vessel Occlusion Model
نویسندگان
چکیده
منابع مشابه
Mouse Transient Global Ischemia Two-Vessel Occlusion Model.
Transient global ischemia in rodents induces delayed death of hippocampal CA1 neurons, as well as in some hilar neurons of the dentate gyrus, medium aspiny neurons of the striatum, pyramidal neurons in neocortical layers II, V and VI, and Purkinje neurons of the cerebellum. In contrast to focal ischemia that mimics regional stroke in humans, this model of global ischemia mimics the brain injury...
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Cerebral ischemia is widely studied through the employment of experimental animal models. Incomplete global models such as two-vessel occlusion are relevant in the study of disease states which may attenuate cerebral ischemia. Hyperglycemia is known to worsen the consequences of ischemia but has not been exclusively employed. The two-vessel occlusion model, which is unsuccessful when employed i...
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Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
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Cardiac arrest followed by resuscitation often results in dramatic brain damage caused by ischemia and subsequent reperfusion of the brain. Global brain ischemia produces damage to specific brain regions shown to be highly sensitive to ischemia (1). Hippocampal neurons have higher sensitivity to ischemic insults compared to other cell populations, and specifically, the CA1 region of the hippoca...
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Alterations in energy substrate utilization during reperfusion of ischemic hearts can influence the functional recovery of the myocardium. Energy substrate preference by the reperfused myocardium, however, has received limited attention. Therefore, we measured oxidation rates of glucose and palmitate during reperfusion of ischemic hearts. Isolated working rat hearts were perfused with 1.2 mM pa...
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ژورنال
عنوان ژورنال: BIO-PROTOCOL
سال: 2012
ISSN: 2331-8325
DOI: 10.21769/bioprotoc.262